We deliver gene therapies
Guide has developed methods to perform thousands of in vivo drug delivery experiments at once. Each method is tailored to the payload: mRNA delivery is studied using mRNA, and siRNA delivery is studied using siRNA. Our approach, which has led to awards including Top 10 Emerging Technologies in the World by the World Economic Forum, allows us to pursue gene therapies in cells that cannot be targeted otherwise.
SCIENTIFIC AMERICAN | 2019
Could the Next Big Information Technology Be ... DNA? How DNA is used to store—and generate-information at extreme scales
In this piece, Guide co-founder James Dahlman describes how DNA can be used to store information. The DNA barcoding process Guide Therapeutics uses to efficiently create safer gene therapies is highlighted.
JACS | 2018
Nanoparticles That Deliver RNA to Bone Marrow Identified by in Vivo Directed Evolution
Using DNA barcoding, nanoparticles that deliver siRNA to bone marrow endothelial cells are identified. This paper includes two important scientific advances. First, bone marrow endothelial cells had not been efficiently targeted by nanoparticles before. Second, the paper utilizes iterative nanoparticle barcoding; the chemical structures that promoted nanoparticle delivery in the first experiment informed the design of nanoparticles in the second experiment.